Home > Medical Reference > Patient EducationServices at Maryland GeneralA complete list of inpatient and outpatient healthcare services at MGH.Skin wrinkles and blemishes - Risk Factors
DescriptionAn in-depth report on the treatment and prevention of skin wrinkles and blemishes.Alternative NamesLiver spots; Pupura; Seborrheic keratoses; Cosmetic surgery; Plastic surgery Risk Factors:Exposure to Sun in Childhood. It is estimated that 50 - 80% of skin damage occurs in childhood and adolescence from intermittent, intense sun exposure that causes severe sunburns. In spite of this now well-known effect, many people still believe that a tan is a sign of good health in children. Even though many parents are concerned about sun exposure, they still rely too much on sunscreen and not enough on protective clothing. The Elderly. Most people over 70 have at least one skin disorder, and many have three or four skin disorders. Everyone experiences skin changes as they age, but a long life is not the sole determinant of aging skin. Family history, genetics, and behavioral choices all have a profound impact on the onset of aging-skin symptoms. Activities Leading to Overexposure to Sunlight and Ultraviolet RadiationOf all the risk factors for aging skin, exposure to UV radiation from sunlight is by far the most serious. The vast majority of undesirable consequences of aging skin occur in individuals who are repetitively exposed to the sun, including the following:
Skin TypesExperts have devised a classification system for skin phototypes (SPTs) based on the sensitivity to sunlight. It ranges from SPT I (lightest skin plus other factors) to IV (darkest skin). People with skin types I and II are at highest risk for photoaging skin diseases, including cancer. It should be noted, however, that premature aging from sunlight can affect people of all skin shades.
GenderThe common belief is that women are at greater risk for wrinkles than men. Some evidence suggests, however, that given the same risk factors, men and women in the same age groups have comparable risks for skin photoaging. Some studies report that men are more likely than women to develop non-melanoma skin cancers. SmokersHeavy smokers are almost five times more likely to have wrinkled facial skin than nonsmokers, according to one study. The skin of smokers in areas of their bodies not exposed to sunlight also seems to age more rapidly compared to nonsmokers in the same age group. In fact, heavy smokers in their 40s often have facial wrinkles more like those of nonsmokers in their 60s. Studies of identical twins have found smokers to have thinner skin (in some cases by as much as 40%), more severe wrinkles, and more gray hair than their nonsmoking twins. Cigarette smokers are also more prone to skin cancers, including squamous cell carcinoma and giant basal cell carcinoma. Research has found that women who smoke have much lower levels of vitamin E secretions in their skin. Vitamin E is an antioxidant that may help protect the skin from sun damage. [For more information, see In-Depth Report #41: Smoking.] Resources
ReferencesAlexiades-Armenakas MR, Dover JS, Arndt KA. The spectrum of laser skin resurfacing: Nonablative, fractional, and ablative laser resurfacing. J Am Acad Dermatol. 2008;58:719-737. Autier P, Gandini S. Vitamin D Supplementation and Total Mortality : A Meta-analysis of Randomized Controlled Trials. Arch Intern Med. 2007;167:1730-1737. Cho HS, Lee MH, Lee JW, et al. Anti-wrinkling effects of the mixture of vitamin C, vitamin E, pycnogenol and evening primrose oil, and molecular mechanisms on hairless mouse skin caused by chronic ultraviolet B irradiation. Photodermatol Photoimmunol Photomed. 2007;23(5):155-62. Chos S, Kim HH, Lee MJ, Lee S, Park CS, Nam SJ, et al. Phosphatidylserine prevents UV-induced decrease of type I procollagen and increase of MMP-1 in dermal fibroblasts and human skin in vivo. J Lipid Res. 2008;49:1235-1245. Fourtanier A, Moyal D, Selt S. Sunscreens containing the broad-spectrum UVA absorber, Mexoryl SX, prevent the cutaneous detrimental effects of UV exposure: a review of clinical study results. Photodermatol Photoimmunol Photomed. 2008;24:164-174. Haftek M, Mac-Mary S, Le Bitoux MA, Creidi P, Selt S, Rougier A, et al. Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin. Exp Dermatol. 2008;17:946-952. Helfrich YR, Yu L, Ofori A, et al. Effect of smoking on aging of photoprotected skin: evidence gathered using a new photonumeric scale. Arch Dermatol. 2007;143(3):397-402. Hercberg S, Ezzedine K, Guinot C, et al. Antioxidant supplementation increases the risk of skin cancers in women but not in men. J Nutr. 2007;137(9):2098-105. Kawada A, Konishi N, Oiso N, Kawara S, Date A. Evaluation of anti-wrinkle effects of a novel cosmetic containing niacinamide. J Dermatol. 2008;35:637-642. Orringer JS, Hammerberg C, Hamilton T, Johnson TM, Kang S, Sachs DL. Molecular effects of photodynamic therapy for photoaging. Arch Dermatol. 2008;144:1296-1302. Ritti L, Kang S, Voorhees JJ, Fisher GJ. Induction of collagen by estradiol: difference between sun-protected and photodamaged human skin in vivo. Arch Dermatol. 2008;144:1129-1140. Selt S, Fourtanier A. The benefit of daily photoprotection. J Am Acad Dermatol. 2008;58:S160-S166. Ward PD, Baker SR. Long-term results of carbon dioxide laser resurfacing of the face. Arch Facial Plast Surg. 2008;10:238-243.
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