Definition of Macroamylasemia:

Macroamylasemia is the buildup of a molecule, called macroamylase, in the blood.

Causes, incidence, and risk factors:

Macroamylase is a molecule that consists of an enzyme, called amylase, bound to a protein. Because it is relatively large, macroamylase is filtered very slowly from the blood by the kidneys.

Macroamylasemia has been associated with:

• Celiac disease
• Ulcerative colitis
• Rheumatoid arthritis
• Lymphoma
• HIV infection
• Monoclonal gammopathy