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Infertility - Overview

Alternative Names

Barren; Inability to conceive; Unable to get pregnant

Definition of Infertility:

Infertility is the inability to become pregnant after 12 months of unprotected sex (intercourse).

Causes, incidence, and risk factors:

Primary infertility is the term used to describe a couple that has never been able to achieve a pregnancy after at least 1 year of unprotected sex.

Secondary infertility describes couples who have been pregnant at least once, but have not been able to achieve a pregnancy again.

Causes of infertility include a wide range of physical and emotional factors. About 30 - 40% of all infertility is due to a "male" factor such as:

Some factors that affect sperm count are:

  • Heavy marijuana use
  • Use of prescription drugs such as cimetidine, spironolactone, and nitrofurantoin

"Female" factor causes include:

  • Abnormal egg transport from the cervix through the fallopian tubes (causes 40 - 50% of infertility in couples)
  • Hormone imbalance
  • Ovarian cysts
  • Pelvic infection
  • Poor nutrition
  • Problem with ovulation
  • Scarring from sexually transmitted disease or endometriosis
  • Tumor

The other 10 -30% of infertility cases may be caused by factors from both partners, or no cause that can be identified.

About 10 - 20% of couples will be unable to conceive after 1 year of trying to become pregnant. It is important that you try to get pregnant for at least 1 year.

The chances for a pregnancy in healthy couples who are both under the age of 30 and having sex regularly is only 25 - 30% per month. A woman's peak fertility occurs in her early 20s. As a woman ages beyond 35 (and especially after age 40), the likelihood of getting pregnant drops to less than 10% per month.

In addition to age-related factors, other infertility risks include:

  • Reviewed last on: 2/5/2008
  • Peter Chen, MD, Department of Obstetrics & Gynecology, University of Pennsylvania Medical Center, Philadelphia, PA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

References

Speroff L, Fitz M. Clinical Gynecologic Endocrinology and Infertility. 7th ed. Lippincott Williams & Wilkins; 2004.

Stenchever A. Comprehensive Gynecology. 4th ed. St. Louis, Mo: Mosby; 2001:1204-1206.

     
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