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Oral cancer - Overview

Alternative Names

Cancer - mouth; Mouth cancer; Head and neck cancer; Squamous cell cancer - mouth

Definition of Oral cancer:

Oral cancer is cancer of the mouth.

Causes, incidence, and risk factors:

Oral cancer most commonly involves the lips or the tongue. It may also occur on the:

  • Cheek lining
  • Floor of the mouth
  • Gums (gingiva)
  • Roof of the mouth (palate)

Most oral cancers are a type called squamous cell carcinomas. These tend to spread quickly.

Smoking and other tobacco use are linked to most cases of oral cancer. Heavy alcohol use also increases your risk for oral cancer.

Other factors that may increase the risk for oral cancer include:

  • Chronic irritation (such as from rough teeth, dentures, or fillings)
  • Human papilloma virus (HPV) infection
  • Taking medications that weaken the immune system (immunosuppressants)
  • Poor dental and oral hygiene

Some oral cancers begin as a white plaque (leukoplakia) or as a mouth ulcer.

Men get oral cancer twice as often as women do, particularly men older than 40.

  • Reviewed last on: 2/28/2011
  • David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; Seth Schwartz, MD, MPH, Otolaryngologist, Virginia Mason Medical Center, Seattle, Washington. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

References

National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology: Head and Neck Cancers. National Comprehensive Cancer Network; 2009. Version 2.2009.

Posner M. Head and neck cancer. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 200.

Wein RO, Malone JP, Weber RS. Malignant neoplasms of the oral cavity. In: Flint PW, Haughey BH, Lund VJ, et al, eds. Cummings Otolaryngology Head and Neck Surgery. 5th ed. St. Louis, Mo: Mosby Elsevier; 2010:chap 96.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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