Symptoms:

• Passing large amounts of urine, which can lead to dehydration
• Bone pain
• Weakness

Signs and tests:

Laboratory tests may show that excess amounts of the following substances may be lost in the urine:

• Amino acids
• Bicarbonate
• Glucose
• Magnesium
• Phosphate
• Potassium
• Sodium
• Uric acid

Loss of these substances can lead to a variety of problems. Further tests and a physical exam may show signs of:

• Dehydration due to excess urination
• Growth failure
• Osteomalacia
• Rickets
• Type 2 renal tubular acidosis