Palonosetron (Injection)

Introduction:

Palonosetron Hydrochloride (pal-oh-NOE-se-tron hye-droe-KLOR-ide)

Prevents nausea and vomiting that could be caused by cancer treatments (chemotherapy) or surgery.

Brand Name(s):

Aloxi

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to palonosetron.

How to Use This Medicine:

Injectable

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given through a needle placed in one of your veins.
  • This medicine is usually given about 30 minutes before the start of chemotherapy or right before you receive anesthetic medicine for surgery.
  • A nurse or other trained health professional will give you this medicine.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding.
  • Tell your doctor if you have had an allergic reaction to similar medicines such as alosetron (Lotronex®), ondansetron (Zofran®), dolasetron (Anzemet®), or granisetron (Kytril®).

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Confusion, weakness, shortness of breath, or numbness or tingling in your hands, feet, or lips.
  • Dry mouth, increased thirst, muscle cramps, nausea, or vomiting.
  • Fast, slow, or uneven heartbeat.
  • Lightheadedness or fainting.

If you notice these less serious side effects, talk with your doctor:

  • Constipation or diarrhea.
  • Headache or dizziness.
  • Pain, burning, redness, swelling, or a lump under your skin where the needle is placed.
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