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Antidepressant medications - selective serotonin reuptake inhibitors (SSRIs)


Medications


Depletions

Melatonin

Reduced levels of melatonin in the body have been associated with sleep disturbances and jet lag.

Protein & Amino Acids

Protein deficiencies are characterized by weakened immune status, including increased susceptibility to infection, impaired wound healing, muscle and weight loss, growth retardation, and deterioration in skin and hair condition.


Editorial Note

The selected depletions information presented here identifies some of the nutrients that may be depleted by certain medications. The signs and symptoms associated with nutrient deficiency may also indicate conditions other than nutrient deficiency. If you are experiencing any of the signs or symptoms mentioned, it does not necessarily mean that you are nutrient deficient. Nutrient depletion depends upon a number of factors, including your medical history, diet, and lifestyle as well as the length of time you have been taking the medication. Please consult your healthcare provider; he or she can best assess and address your individual healthcare needs, and determine if you are at risk for nutrient depletions from these medications as well as others not listed here.


Supporting Research

Avery D, Lenz M, Landis C. Guidelines for prescribing melatonin. Ann Med . 1998;30:122-130.

Childs PA, Rodin I, Martin NJ, et al. Effect of fluoxetine on melatonin in patients with seasonal affective disorder and matched controls. Br J Psychiatry . 1995;166:196-198.

Covington T, ed. Nonprescription Drug Therapy Guiding Patient Self-Care . St Louis, MO: Facts and Comparisons; 1999:467-545.

Urdaneta E, Idonte I, Larraldo J. Drug-nutrient interactions: inhibition of amino acid intestinal absorption by fluoxetine. Br J Nutr . 1998;79(5):439-446.


  • Review Date: 10/1/2000
  • Reviewed By: All depletions monographs have been reviewed by a team of experts including Derrick M. DeSilva, Jr., MD, Raritan Bay Medical Center, Perth Amboy, NJ; Jacqueline A. Hart, MD, Department of Internal Medicine, Newton-Wellesley Hospital, Harvard University and Senior Medical Editor, A.D.A.M., Inc., Boston, MA; John Hinze, PharmD, NMD, Woodbine, IA; Ruth Marlin, MD, Medical Director and Director of Medical Education, Preventive Medicine Research Institute, Sausalito, CA; Brian T Sanderoff, PD, BS in Pharmacy, Clinical Assistant Professor, University of Maryland School of Pharmacy; President, Your Prescription for Health, Owings Mills, MD; Leonard Wisneski, MD, FACP, George Washington University, Rockville, MD; Ira Zunin, MD, MPH, MBA, President and Chairman, Hawaii State Consortium for Integrative Medicine, Honolulu, HI.
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